Serracor-NK is a powerful blend of antioxidant herbs, CoEnzyme q10 and magnesium with enteric coated serrapeptase and nattokinase, systemic enzymes studied for their fibrinolytic properties. Serracor-NK supports a healthy circulatory system and normal fibrin metabolism.
Serracor-NK, 300 capsules $124.95 + 6.50
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Serracor-NK Professional-Strength Fibrinolytic Enzyme Blend
Serracor-NK™ contains the original Neprinol® formula, which contains SEBkinase® with enteric coated serrapeptase and nattokinase. We are the original manufacturer of this formula, imitated by many others. Read more at the bottom of the page.
Enteric coated Serrapeptase and Nattokinase: Why is it important?
Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.
How do Fibrinolytic Units (FU's) relate to enteric coating?
Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach. Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach). In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.
The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines. If your enzyme formula is not enteric coated, you may be wasting your money.
Serracor-NK for Circulatory Support
Did you know cardiovascular disease is the biggest killer in America? Arterial plaque build-up, excessive fibrin levels and metabolic waste matter slow normal blood circulation. A healthy vascular system must supply oxygenated blood to vital organs including the heart and brain.
Serracor-NK supports the body’s natural response to inflammation, normalizes fibrin levels in the circulatory system, reduces C-reactive protein levels, and normalizes blood viscosity and platelet stickiness.*
SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum cardiovascular health.*
Serracor-NK also promotes healthy levels of C-reactive protein, an inflammation marker and serious risk factor for cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System™ (BPPS).
Fibrin performs an important function in the body, including clotting and wound healing. However, excessive fibrin can impede normal blood flow, which may lead to increased blood viscosity, swelling, edema, pain, inflammation and more serious cardiovascular events. The proteases in Serracor-NK support normal fibrin levels, blood viscosity and overall blood circulation.*
For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit).
NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day.
Serracor-NK Side Effects
There appear to be no side effects when taking oral enzymes for a long-term duration. Gastrointestinal disturbances may occur in individual cases, and minor allergic reactions (reddening of the skin) are rare and only occur with high doses. Long-term usage of supplemental enzymes has not been found to be detrimental.
If you are taking anticoagulants, like warfarin type of drugs, do not take this product without consulting your physician. If you are pregnant or nursing, consult your healthcare professional before using this or any dietary supplement.
Nattokinase Research: Fibrinoyltic Activity
In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1 A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke. It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure. Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4
A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity. The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time. The results indicate natto generates an increased ability to dissolve blood clots. As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity. The tests showed no significant change.5
The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event. For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted. The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7
Nattokinase Benefits & Blood Clots
Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system. These clots can cause blockage of blood flow. If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies. In the heart, this can result in myocardial infarction (heart attack). In the brain, it can result in strokes or mini-strokes. Deep vein thrombosis can result in pulmonary emboli. All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity. The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8
The process of forming a clot is complex and involves several enzymes. However, the body mainly produces one central enzyme for dissolving a clot, plasmin. It happens that the properties of nattokinase are very similar to plasmin. Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways. It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase. An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats. A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9
A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses. The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals. After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group. The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10
Serrapeptase Benefits and Respiratory Health
When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health.
Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11
Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12
The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13
Neprinol vs Serracor NK Brand Comparison
Enzyme Stabilization with BPPS®
The Bioactive Protein Peptides System® (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes.
The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies specifically for enzyme stability. Stabilizers have been used since we began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by Specialty Enzymes in the early 1990's.
It is true it was not trademarked until
2008, but it was in use long before. The
reality is, a pure enzyme is not stable. It
requires the addition of stabilizers in
order to provide a reasonable shelf life.
Because we are the actual manufacturer of
enzymes with more than 50 years of
manufacturing experience, our research and
development team constantly works to improve
stability and tolerance to the environments
in which the enzymes interact. Marketing
companies, on the other hand, will generally
have significantly less understanding of the
physio-chemical and kinetic properties of
Make an Informed Choice
There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.